Serial electrocardiograms were carried out in the WHI CaD Study

A statistical analysis proposal was submitted to the institute before the database was made available.We attempted to replicate the approach of the WHI investigators where possible, carrying out pre specified analyses looking for interactions between pre specified subgroups based on use (no use v any use) and dose (0, 1 499 pandora necklaces, 500 999, 1000 mg/day) of personal calcium supplements at randomisation for cardiovascular events. We pre specified assessment of four cardiovascular end points and their combinations: myocardial infarction, coronary revascularisation (coronary artery bypass grafting or percutaneous coronary intervention), death from coronary heart disease, and stroke. Serial electrocardiograms were carried out in the WHI CaD Study, allowing detection of silent myocardial infarctions.

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